IP forwarding alternatives in cell switched optical networks

Optical switching will enable core Internet packet switching to scale with future transmission rate increases. Currently proposed optical ATM switches do not allow packet reassembly, which is necessary for packet level forwarding. This results in the requirement to create end to end ATM virtual connections for flows even if they contain only one packet. In electronically switched networks MPOA and MPLS allow both cell and packet level forwarding to overcome this problem. This paper examines the feasibility of implementing such protocols over an optically switched network. Two different architectures are examined: use of an adjunct electrical router; and native optical packet reassembly. An examination of the optical reassembly buffer requirements show that the use of MPLS will require significantly more buffering than MPOA

An examination of IP/ATM cut-through forwarding in dynamically routed networks

Multiprotocol over ATM (MPOA), IP switching and multiprotocol label switching (MPLS) have distinctly different mechanisms for cut-through packet forwarding. MPOA and IP switching use flow-based cut-through (FBC) forwarding while MPLS uses routing table linked cut-through forwarding (TLC). This paper examines the sensitivity of each these cut-through forwarding mechanisms to changes in underlying routing tables. We examine a scenario where a congestion-sensitive dynamic routing protocol, such as OSPF optimised multipath, leads to frequently changing routing tables. We show that FBC forwarding reacts significantly worse than flow length distributions predict, taking up to 1200 seconds to react to route changes and forward at least 50% of packets on the new route. Flow characteristics are examined to determine ways to improve FBC sensitivity. We show that implementing a maximum flow length of 200 seconds improves the response to route changes significantly with a minimal decrease in the number of switched packets (1.5%)

Investigation and modelling of traffic issues in immersive audio environments

Copyright © 2004 IEEEA growing area of technical importance is that of distributed virtual environments for work and play. For the audio component of such environments to be useful, great emphasis must be placed on the delivery of high quality audio scenes in which participants may change their relative positions. In this paper we describe and analyze an algorithm focused on maintaining relative synchronization between multiple users of such an environment and examine the subjective quality of service achieved

Enhancing the multicast performance of structured P2P overlay in supporting Massively Multiplayer Online Games

Scribe is a scalable application level multicast infrastructure. We have developed two techniques to improve the performance of Scribe in terms of latency and bandwidth distribution. The first technique identifies that the final hop of Scribe traffic path is largely selected without any proximity consideration and incurs the longest distance traveled. To overcome this, we introduce Proximity Neighbor Selection (PNS) into the final hop for latency improvement. The second technique builds a hierarchical two-level overlay. While PNS can be applied at both levels for latency performance, the bandwidth stress required by applications can now be distributed among the nodes in the higher level overlay. Our simulation using GT-ITM topology has shown that both techniques have improved the latency performance for more than 30 percent, and the two-level overlay has improved the bandwidth distribution up to 2.7 times, comparing with what can be achieved by a standard Scribe overlay. We have developed the techniques in the context of Massively Multiplayer Online Games (MMOGs). While Scribe provides a possible platform for the scalable deployment of MMOGs, game developers may leverage the techniques to enhance the design of real-time interactions between players in the game world

Informal Action—Adjudication—Rule Making: Some Recent Developments in Federal Administrative Law

Direct energy consumption of ICT hardware is only “half the story.” In order to get the “whole story,” energy consumption during the entire life cycle has to be taken into account. This chapter is a first step toward a more comprehensive picture, showing the “grey energy” (i.e., the overall energy requirements) as well as the releases (into air, water, and soil) during the entire life cycle of exemplary ICT hardware devices by applying the life cycle assessment method. The examples calculated show that a focus on direct energy consumption alone fails to take account of relevant parts of the total energy consumption of ICT hardware as well as the relevance of the production phase. As a general tendency, the production phase is more and more important the smaller (and the more energy-efficient) the devices are. When in use, a tablet computer is much more energy-efficient than a desktop computer system with its various components, so its production phase has a much greater relative importance. Accordingly, the impacts due to data transfer when using Internet services are also increasingly relevant the smaller the end-user device is, reaching up to more than 90 % of the overall impact when using a tablet computer.QC 20140825</p

Surgical correction of a persistent right aortic arch in a kitten with concurrent mitral and tricuspid valve insufficiency and long-term post-operative management of residual megaoesophagus

A Maine Coon kitten was diagnosed with persistent right aortic arch and concurrent mitral and tricuspid valve insufficiency. Diuretic and positive inotropic treatment were administered before surgical treatment was attempted. Surgical ligation of the ligamentum arteriosum was performed successfully. Regurgitation did not resolve despite efforts to slowly introduce solid food to the diet over a period of two months. The kitten suffered from several incidences of aspiration pneumonia that responded to antibiotic treatment. Follow-up computed tomography ruled-out extraluminal constriction of the oesophagus, and oesophagoscopy confirmed a residual megaoesophagus six months post-operatively. The kitten was euthanised seven months after surgery. The importance of a complete cardiac work-up and oesophagoscopy in suspected vascular ring anomaly examinations are highlighted in this case study.https://bvajournals.onlinelibrary.wiley.com/journal/205261212022-06-09hj2022Companion Animal Clinical Studie

Contemporary update of cancer control after radical prostatectomy in the UK

Despite a significant increase of the number of radical prostatectomies (RPs) to treat organ-confined prostate cancer, there is very limited documentation of its oncological outcome in the UK. Pathological stage distribution and changes of outcome have not been audited on a consistent basis. We present the results of a multicentre review of postoperative predictive variables and prostatic-specific antigen (PSA) recurrence after RP for clinically organ-confined disease. In all, 854 patient's notes were audited for staging parameters and follow-up data obtained. Patients with neoadjuvant and adjuvant treatment as well as patients with incomplete data and follow-up were excluded. Median follow-up was 52 months for the remaining 705 patients. The median PSA was 10 ng ml−1. A large migration towards lower PSA and stage was seen. This translated into improved PSA survival rates. Overall Kaplan–Meier PSA recurrence-free survival probability at 1, 3, 5 and 8 years was 0.83, 0.69, 0.60 and 0.48, respectively. The 5-year PSA recurrence-free survival probability for PSA ranges 20 ng ml−1 was 0.82, 0.73, 0.59 and 0.20, respectively (log rank, P<0.0001). PSA recurrence-free survival probabilities for pathological Gleason grade 2–4, 5 and 6, 7 and 8–10 at 5 years were 0.84, 0.66, 0.55 and 0.21, respectively (log rank, P<0.0001). Similarly, 5-year PSA recurrence-free survival probabilities for pathological stages T2a, T2b, T3a, T3b and T4 were 0.82, 0.78, 0.48, 0.23 and 0.12, respectively (log rank, P=0.0012). Oncological outcome after RP has improved over time in the UK. PSA recurrence-free survival estimates are less optimistic compared to quoted survival figures in the literature. Survival figures based on pathological stage and Gleason grade may serve to counsel patients postoperatively and to stratify patients better for adjuvant treatment

Methylation of HOXA9 and ISL1 predicts patient outcome in high-grade non-invasive bladder cancer

Introduction Inappropriate DNA methylation is frequently associated with human tumour development, and in specific cases, is associated with clinical outcomes. Previous reports of DNA methylation in low/intermediate grade non-muscle invasive bladder cancer (NMIBC) have suggested that specific patterns of DNA methylation may have a role as diagnostic or prognostic biomarkers. In view of the aggressive and clinically unpredictable nature of high-grade (HG) NMIBC, and the current shortage of the preferred treatment option (Bacillus:Calmette-Guerin), novel methylation analyses may similarly reveal biomarkers of disease outcome that could risk-stratify patients and guide clinical management at initial diagnosis. Methods Promoter-associated CpG island methylation was determined in primary tumour tissue of 36 initial presentation high-grade NMIBCs, 12 low/intermediate-grade NMIBCs and 3 normal bladder controls. The genes HOXA9, ISL1, NKX6-2, SPAG6, ZIC1 and ZNF154 were selected for investigation on the basis of previous reports and/or prognostic utility in low/intermediate-grade NMIBC. Methylation was determined by Pyrosequencing of sodium-bisulphite converted DNA, and then correlated with gene expression using RT-qPCR. Methylation was additionally correlated with tumour behaviour, including tumour recurrence and progression to muscle invasive bladder cancer or metastases. Results The ISL1 genes’ promoter-associated island was more frequently methylated in recurrent and progressive high-grade tumours than their non-recurrent counterparts (60.0% vs. 18.2%, p = 0.008). ISL1 and HOXA9 showed significantly higher mean methylation in recurrent and progressive tumours compared to non-recurrent tumours (43.3% vs. 20.9%, p = 0.016 and 34.5% vs 17.6%, p = 0.017, respectively). Concurrent ISL1/HOXA9 methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year (Positive Predictive Value 91.7%), and was associated with disease-specific mortality (DSM). Conclusions In this study we report methylation differences and similarities between clinical sub-types of high-grade NMIBC. We report the potential ability of methylation biomarkers, at initial diagnosis, to predict tumour recurrence and progression within one year of diagnosis. We found that specific biomarkers reliably predict disease outcome and therefore may help guide patient treatment despite the unpredictable clinical course and heterogeneity of high-grade NMIBC. Further investigation is required, including validation in a larger patient cohort, to confirm the clinical utility of methylation biomarkers in high-grade NMIBC

Label switching using the IPv6 address hierarchy

Current label switching protocols can use routing, address, and address hierarchy information to group flows for cut-throughs that bypass IP forwarding. This paper examines a label switching solution that uses the IP version 6 (IPv6) address structure to classify and cut-through flows based on address hierarchy. The performance of this approach is examined using actual backbone traffic traces with associated hierarchical address information obtained from Internet address registries, routing arbiter databases and route servers. This hierarchical address information is used to map a hierarchical address structure over the packet level trace. We investigate the relationship between aggregation bit-mask size versus label switching performance. We show that aggregation greater than IPv6 destination site address does not significantly improve performance. Our trace driven simulation studies show that it is possible to reduce the network layer packet forwarding requirements to below 0.15% of total packets at boundary routers within the core network by using IPv6 address hierarchy linked label switching

Managing latency and fairness in networked games

Networked games can be seen as forerunners of all kinds of participatory entertainment applications delivered through the Internet. Physically dispersed players are immersed in a common virtual environment where they interact in real time. When a user performs an action, other users must be made aware of that action. Otherwise, there is a discrepancy in the perceptions of participants about the overall state of the virtual world. This discrepancy could lead to undesirable and sometimes paradoxical outcomes. In particular, first-person shooter, and to a lesser extent role-playing games impose stringent constraints on responsiveness and consistency